AA

Anaplastic Anemia. Anaplastic Anemia is an uncommon disease resulting in deficiencies of blood cell production by bone marrow.

CERF Crossreference annotation ID: anaplastic-anemia

ABC

Advanced Breast Cancer. Metastatic or Stage IV breast cancer.

CERF Crossreference annotation ID: advanced-breast-cancer

ABCD

Asymmetry, Border, Color, and Diameter. These are characteristics commonly used to asses if a mole is showing signs of skin cancer.

CERF Crossreference annotation ID: asymmetry-border-color-diameter

AD

Alzheimer’s Disease. This is a dementia that leads to deterioration of important mental functions such as thinking.

CERF Crossreference annotation ID: alzheimers-disease

ADCC

Antibody-Dependent Cellular Cytotoxicity. A cell-mediated immune defense mechanism in which the immune system actively breaks down the membrane of a target cell.

CERF Crossreference annotation ID: antibody-dependent-cellular-cytotoxicity

Adenocarcinoma

A malignant tumor that arises in mucus-secreting glands.

CERF Crossreference annotation ID: adenocarcinoma

Adjunct Agent

A drug or substance used alongside a primary therapy during cancer therapy.

CERF Crossreference annotation ID: adjunct-agent

Adjuvant Chemotherapy

While chemotherapy is generally a standalone treatment or used in conjunction with radiation following surgical resection, adjuvant chemotherapy describes the use of chemotherapy in comparison to other cancer treatments.

CERF Crossreference annotation ID: adjuvant-chemotherapy

Adjuvant Radiation Therapy

Radiation therapy used after primary treatment for the prevention of a cancer relapse.

CERF Crossreference annotation ID: adjuvant-radiation-therapy

AGC

Atypical Glandular Cells. This diagnoses results from the appearance of cytological abnormalities in glandular cells that do not demonstrate all the characteristics of adenocarcinomas.

CERF Crossreference annotation ID: atypical-glandular-cells

AIDS

Acquired Immune Deficiency Syndrome. The final stage of HIV where the T-cell (CD4 cell) count falls below 200.

CERF Crossreference annotation ID: acquired-immune-deficiency-syndrome

ALAT / ALT

Alanine aminotransferase / alanine transaminase. ALAT is a catalyst of two parts of the alanine cycle, found in plasma and body tissues, most commonly found in the liver.

CERF Crossreference annotation ID: alanine-aminotransferase

ALCL

Anaplastic Large-cell Lymphoma. This is a rare form of non-Hopkins lymphoma (NHL), but is more commonly seen as a T-cell lymphoma.

CERF Crossreference annotation ID: anaplastic-large-cell-lymphoma

ALK

Anaplastic Lymphoma Kinase. ALK is one of the receptor tyrosine kinase (RTK) family of enzymes, which have significant roles in the proliferation and differentiation of cells. Recent studies have suggested that ALK may be a key target for drug development in oncological medicine. Read more at https://pubmed.ncbi.nlm.nih.gov/21642865/

CERF Crossreference annotation ID: anaplastic-lymphoma-kinase

ALL

Acute Lymphocytic Leukemia. A fast-growing cancer of the antibody-producing lymphocytes. This disease is characterized by a greater presence of immature lymphocytes (lymphoblasts) than normally needed in the blood and bone marrow, and is the most common of pediatric cancers.

CERF Crossreference annotation ID: acute-lymphocytic-leukemia

ALPS

Autoimmune Lymphoproliferative Syndrome. Also known as Canale-Smith Syndrome. This is a rare, genetic lymphoproliferative disorder that affects lymphocyte apoptosis.

CERF Crossreference annotation ID: autoimmune-lymphoproliferative-syndrome

AMKL

Acute Megakaryocytic Leukemia. This is a rare type of leukemia where most of the blasts are megakaryoblastic.

CERF Crossreference annotation ID: acute-megakaryocytic-leukemia

AML

Acute Myeloid Leukemia. A form of cancer characterized by the presence of too many immature granulocytes in the bone marrow and blood.

CERF Crossreference annotation ID: acute-myeloid-leukemia

ANA

Antinuclear Antibodies. Antibodies attack “normal” proteins found in the cellular nucleus. High levels of ANAs can trigger the body to begin attacking itself, leading to autoimmune diseases.

CERF Crossreference annotation ID: antinuclear-antibodies

Anaplastic

Cancer cells that proliferate quickly and unlike normal cells.

CERF Crossreference annotation ID: anaplastic

ANLL

Acute Non-Lymphocytic Leukemia. Too many immature white blood cells are present in the blood and bone marrow. ANLL is also known as Acute Myeloid Leukemia.

CERF Crossreference annotation ID: acute-non-lymphocytic-leukemia

Antigen

A foreign substance that results in the body triggering an immune response.

CERF Crossreference annotation ID: antigen

APL

Acute Promyelocytic Leukemia. This is a form of AML in which excess amounts of promyelocytes (immature white blood cells) are found in bone marrow.

CERF Crossreference annotation ID: acute-promyelocytic-leukemia

Archived Tumor Sample

Tumor sample preserved and stored through common processes.

CERF Crossreference annotation ID: archived-tumor-sample

ARMS

Alveolar Rhabdomyosarcoma. This is a cancer that usually affects the skeletal cells in the trunk, arms, and legs.

CERF Crossreference annotation ID: alveolar-rhabdomyosarcoma

Aromatase Inhibitor

Medication that inhibits the aromatase enzyme, resulting in decreased levels of estrogen in the body.

CERF Crossreference annotation ID: aromatase-inhibitor

ASPS

Alveolar Soft Part Sarcoma. This is a rare soft-tissue sarcoma typically found in children and young adults. ASPS is extremely uncommon and grows very slowly, making early detection difficult.

CERF Crossreference annotation ID: alveolar-soft-part-sarcoma

ATC

Anaplastic Thyroid Cancer. This is a very aggressive thyroid cancer.

CERF Crossreference annotation ID: anaplastic-thyroid-cancer

B-ALL

B-Cell Acute Lymphoblastic Leukemia. A type of clonal malignancy characterized by excess accumulation of lymphoblasts that phenotypically resemble the early stages of normal B-cell differentiation.

CERF Crossreference annotation ID: b-cell-acute-lymphoblastic-leukemia

BC

Breast Cancer. A common cancer that affects women and may rarely affect men. There are several types of breast cancer, and symptoms usually include a lump found in breast tissue or a change to the shape or texture of the breast.

CERF Crossreference annotation ID: breast-cancer

BCC

Basal Cell Carcinoma. BCC is a type of skin cancer that creates lesions and uncontrolled growth in the basal cells of the epidermis.

CERF Crossreference annotation ID: basal-cell-carcinoma

BCL

B Cell Lymphoma. This a a group of both Hodgkin’s and non-Hodgkin’s lymphomas that affect B cells.

CERF Crossreference annotation ID: b-cell-lymphoma

BEB

Benign Essential Blepharospasm. This is a neurological condition in which the eyelid spasms uncontrollably, forcing it to close. The cause of the spasms is unknown.

CERF Crossreference annotation ID: benign-essential-blepharospasm

Biomarker

A biomarker may indicate the presence of a substance that can identify a particular disease or state of infection, as well as give information about the characteristics of a disease. See also: Cluster of differentiation.

CERF Crossreference annotation ID: biomarker

BM

Bone Marrow. Bone Marrow is the tissue found within bones. The production of red blood cells and lymphocytes is among the many vital functions of bone marrow.

CERF Crossreference annotation ID: bone-marrow

BMPM

Benign Multicystic Peritoneal Mesothelioma, a very rare slow-growing tumor.

CERF Crossreference annotation ID: benign-multicystic-peritoneal-mesothelioma

BRAF

B-Raf protein, a proto-oncogene gene that is a member of the kinase family.

CERF Crossreference annotation ID: b-raf-protein

BRCA1 and BRCA2

These genes typically assist in regulating cell growth, and mutations of these genes are the most well-known genes linked to breast and ovarian cancer development.

CERF Crossreference annotation ID: brca1-brca2

BT

Brain Tumor. The causes of a brain tumor are usually unknown, but both benign and malignant tumors can be life-threatening if not treated promptly.

CERF Crossreference annotation ID: brain-tumor

Bx

Biopsy. A tissue sample taken for closer examination or testing, for diagnostic purposes. Samples gathered for this purpose are subject to legally mandated retention protocols, and under certain conditions may be released as specimens for scientific research.

CERF Crossreference annotation ID: biopsy

Ca

Cancer; carcinoma. Cancer is a disease in which some cells begin to replicate uncontrollably and spread into surrounding tissues.

CERF Crossreference annotation ID: carcinoma

Cancer Staging

Assigning a scale number to describe the spreading of a cancer. See Pathologic (or Histologic) Grade for more information.

CERF Crossreference annotation ID: cancer-staging

CBT

Carotid Body Tumor. These are slow-growing tumors located in the neck where the large carotid artery branches apart. These rare tumors are not life-threatening, but may eventually lead to damage to surrounding nerves and blood vessels. CBTs are also known as a chemodectoma or paraganglioma.

CERF Crossreference annotation ID: carotid-body-tumor

CCF

Congestive Cardiac Failure. This is a chronic condition in which the heart is functioning at sub-normal efficiency.

CERF Crossreference annotation ID: congestive-cardiac-failure

CD

Cluster of Differentiation. This is a protocol used for the identification and investigation of cell surface molecules providing targets for the immunophenotyping of cells.

CERF Crossreference annotation ID: cluster-of-differentiation

CEA

Carcinoembryonic Antigen. These are glycoproteins, produced during fetal development, involved in cell adhesion.

CERF Crossreference annotation ID: carcinoembryonic-antigen

CEMA

Chronic Enteroviral Meningoencephalitis in Agammaglobulinemia. This is a complication in X-Linked Agammaglobulinemia patients, and may be caused by viruses that attack that Central Nervous System.

CERF Crossreference annotation ID: chronic-enteroviral-meningoencephalitis-agammaglobulinemia

CGL

Chronic Granulocytic Leukemia. A slow-progressing disease of the blood and bone marrow in which too many granulocytes are produced. This is also known as Chronic Myeloid Leukemia.

CERF Crossreference annotation ID: chronic-granulocytic-leukemia

Chemotherapy

Treating cancer cells through the use of cytotoxic drugs. This treatment may be used alongside surgery, or with alternative treatment options.

CERF Crossreference annotation ID: chemotherapy

Chromosome

A structure found in the nucleus of a cell which carries genetic information.

CERF Crossreference annotation ID: chromosome

CIN

Cervical Intraepithelial Neoplasia. This is a non-cancerous abnormal growth of squamous cells on the cervix’s surface. CIN usually does not require treatment, but a small portion of cases may progress to cancer. CIN is also known as cervical dysplasia.

CERF Crossreference annotation ID: cervical-intraepithelial-neoplasia

CIS

Carcinoma In Situ. CIS is a cluster of abnormal cells that does not spread beyond its tissue of origin. There is debate over whether or not CIS is classified as cancer, however, it is agreed that these cells have the potential to become cancerous.

CERF Crossreference annotation ID: carcinoma-in-situ

CLL

Chronic Lymphocytic Leukemia. This is a type of leukemia that affects cells designated to be white blood cells in the bone marrow, which then move into the blood steam.

CERF Crossreference annotation ID: chronic-lymphocytic-leukemia

CLIA

Clinical Laboratory Improvement Amendments. These federal regulatory standards govern clinical laboratory testing conducted on humans in the United States were established in 1988. Learn more about the Clinical Laboratory Improvement Amendments (CLIA) health and safety standards.

CERF Crossreference annotation ID: clinical-laboratory-improvement-amendments

Clinical Trial

A research study involving human subjects to test the effectiveness and safety of technologies, drugs, and procedures.

CERF Crossreference annotation ID: clinical-trial

Clinically Validated

Ensuring that a procedure, data, or test is correct.

CERF Crossreference annotation ID: clinically-validated

CMI

Cell-Mediated Immunity. This is an immune response to an antigen that actives T-lymphocytes and phagocytes.

CERF Crossreference annotation ID: cell-mediated-immunity

CML

Chronic Myeloid Leukemia. Immature myeloid cells form the abnormal BCR-ABL gene. Also known as chronic myelogenous leukemia.

CERF Crossreference annotation ID: chronic-myeloid-leukemia

CMML

Chronic Myelomonocytic Leukemia. This cancer affects the bone marrow’s blood-forming cells, and spreads into the blood stream.

CERF Crossreference annotation ID: chronic-myelomonocytic-leukemia

CMS

Center for Medicare and Medicaid Services.

CERF Crossreference annotation ID: center-medicare-medicaid-services

CMV

Cytomegalovirus. This is a common virus that, once affected, lasts a lifetime. It is a genus in the order Herpesvirales.

CERF Crossreference annotation ID: cytomegalovirus

COD

Cause of Death.

CERF Crossreference annotation ID: cause-of-death

Colectomy

Surgical removal of damaged colon tissue.

CERF Crossreference annotation ID: colectomy

Colitis

An inflamed colon, which may be present in many forms.

CERF Crossreference annotation ID: colitis

Colon Polyp

A fleshy clump of cells that grow on the inside lining of the colon.

CERF Crossreference annotation ID: colon-polyp

Colonoscopy

An exam conducted to view the conditions of the inside of the colon through the use of a small fiber-optic scope.

CERF Crossreference annotation ID: colonoscopy

Common Rule

45-CFR-46. The Common Rule is a set of federal regulations governing patient protection for research conducted with federal funds, or at sites supported with federal funds.

CERF Crossreference annotation ID: common-rule

Consent

Consent is a crucial regulatory aspect of specimen collection and use. Biorepositories must demonstrate that donors have given informed consent for the samples they donate. IRBs typically establish ethical guidelines for how tissues are collected and used.

CERF Crossreference annotation ID: consent

Core Biopsy

The procedure which obtains a cylindrical tissue sample through the use of a hollow needle, usually used to test for breast cancer.

CERF Crossreference annotation ID: core-biopsy

CPC

Choroid Plexus Carcinoma. CPC is located in ventricles and increases cerebrospinal fluid, which may result in hydrocephalus.

CERF Crossreference annotation ID: choroid-plexus-carcinoma

CRC

Colorectal Carninoma. This is a common cancer that affects the large intestine and/or rectum.

CERF Crossreference annotation ID: colorectal-carninoma

CRO

Contract Research Organization. An organization that performs research services on a contractual basis.

CERF Crossreference annotation ID: contract-research-organization

CSF

Cerebrospinal Fluid. This is a clear, cushioning fluid produced by the choroid plexuses. It is found in the brain and spinal cord.

CERF Crossreference annotation ID: cerebrospinal-fluid

CLSI

Clinical and Laboratory Standards Institute. CLSI is a non-profit organization aimed at developing clinical and laboratory standards.

CERF Crossreference annotation ID: clinical-laboratory-standards-institute

CTC

Circulating Tumor Cell. These are cells from a primary tumor that circulate through the body via the bloodstream. Learn more at https://en.wikipedia.org/wiki/Circulating_tumor_cell

CERF Crossreference annotation ID: circulating-tumor-cell

CTCL

Cutaneous T-cell Lymphoma. CTCL is a non-Hodgkin lymphoma that causes accelerated growth of T-cells.

CERF Crossreference annotation ID: cutaneous-t-cell-lymphoma

CVA

Cerebrovascular Accident. This is a stroke, where blood is unable to reach parts of the brain due to blood vessel ruptures or blockages.

CERF Crossreference annotation ID: cerebrovascular-accident

DAT

Direct Antiglobulin Test. DAT is a blood test that examines if antibodies have attached to the surface antigens of red blood cells. DAT is commonly used to test for autoimmune hemolytic anemia, where red blood cell counts are lowered due to the destruction of red blood cells. The direct antiglobulin test is also known as the direct Coombs test.

CERF Crossreference annotation ID: direct-antiglobulin-test

DHL

Diffuse Histolytic Lymphoma. DHL is a rare and aggressive form of non-Hodgkins lymphoma, characterized by abnormal lymphoid cells.

CERF Crossreference annotation ID: diffuse-histolytic-lymphoma

DI

Diabetes Insipidus. DI is a rare type of diabetes characterized by a deficiency in vasopressin, a hormone produced by the pituitary gland.

CERF Crossreference annotation ID: diabetes-insipidus

Diagnosis

Using examinations, test results, and symptoms to identify a condition.

CERF Crossreference annotation ID: diagnosis

DIG Staining

Digoxigenin, a hapten which can be bound to nucleotides and sugars, is used as an immunohistochemical marker for in situ hybridization.

CERF Crossreference annotation ID: digoxigenin

Distant Recurrence

A cancer affecting parts of the body away from its tissue of origin.

CERF Crossreference annotation ID: distant-recurrence

DLBCL

Diffuse Large B-cell Lymphoma is the most common type of non-Hodgkin lymphoma. It affects lymphocytes, has several subtypes, and is very aggressive.

CERF Crossreference annotation ID: diffuse-large-b-cell-lymphoma

Dukes Staging System

A system consisting of four stages used to assign levels of severity to rectal cancers.

CERF Crossreference annotation ID: dukes-staging-system

Dysplasia

Cells which undergo abnormal changes and may potentially develop into cancer.

CERF Crossreference annotation ID: dysplasia

Early-Stage Invasive Breast Cancer

Stage I, stage II, and in some instances, stage III breast cancer.

CERF Crossreference annotation ID: early-stage-invasive-breast-cancer

EBV

Epstein-Barr Virus. This is human herpesvirus 4, and can lead to infectious monocucleosis.

CERF Crossreference annotation ID: epstein-barr-virus

EGFR

Epidermal Growth Factor Receptor. Regulation of EGFR can be involved with some cancers. Related biomarkers can be used to predict the responsiveness of some cancers to certain treatments.

CERF Crossreference annotation ID: epidermal-growth-factor-receptor

ELN

Electronic Lab Notebook. Used to create records, log experiments and store structured, and unstructured data, images, files and documents in GxP or 21CFR11 regulated environments. Designed specifically for protecting data integrity revealing accurate provenance and controlling local or remote role-based access in a multi-user environment. A good example for use in pathology or related fields is CERF ELN.

CERF Crossreference annotation ID: electronic-lab-notebook

EMC

Extraskeletal Myxoid Chondrosarcoma. This is a very rare soft tissue sarcoma. While it does not progress quickly, this neoplasm has a tendency to recur and metastasize locally.

CERF Crossreference annotation ID: extraskeletal-myxoid-chondrosarcoma

Endoscope

A medical instrument used to examine the internal parts of a body.

CERF Crossreference annotation ID: endoscope

Endoscopy

Examination of an interior body part through the use of an endoscope.

CERF Crossreference annotation ID: endoscopy

ER

Estrogen Receptor. A protein found on some cells that receives hormone signals.

CERF Crossreference annotation ID: estrogen-receptor

FFPE

Formalin Fixed Paraffin Embedded tissues. Sections from a FFPE block, composed of dehydrated tissue fixed with neutral buffered formalin and then infused and embedded in paraffin, are sliced for use.

CERF Crossreference annotation ID: formalin-fixed-paraffin-embedded

FISH

Fluorescence In Situ Hybridization. This is a coming staining/screening technique in which fluorescent probes are used to indicate target sequences on chromosomes.

CERF Crossreference annotation ID: fluorescence-in-situ-hybridization

FNA

Fine Needle Aspiration. A biopsy performed with percutaneous insertion of a very thin needle to draw a fluid sample. Also, may refer to Fine Needle Aspirate, which is the fluid that is gathered by such a procedure.

CERF Crossreference annotation ID: fine-needle-aspiration

Functional Genomics

The global-scale study of gene and protein expression and function through the use of genomic data. Read more at https://en.wikipedia.org/wiki/Functional_genomics

CERF Crossreference annotation ID: functional-genomics

Gastroenterologist

A doctor specializing in gastrointestinal tract diseases.

CERF Crossreference annotation ID: gastroenterologist

Gastroenterology

The medical branch which studies the stomach and intestines.

CERF Crossreference annotation ID: gastroenterology

Gene

Heredity units passed from parent to offspring.

CERF Crossreference annotation ID: gene

Gene Expression

The process of using information from a gene to create a genetic product.

CERF Crossreference annotation ID: gene-expression

Gene Expression Profile

The activity levels of numerous genes from a specimen.

CERF Crossreference annotation ID: gene-expression-profile

Genetics

The study of heredity, genes, and characteristic variations.

CERF Crossreference annotation ID: genetics

Genome

The complete set of DNA for an organism.

CERF Crossreference annotation ID: genome

Genomic Test

A test that examines the changes in gene activity, often used to predict how a cancer may progress or be treated.

CERF Crossreference annotation ID: genomic-test

Genomics

The study of genomes.

CERF Crossreference annotation ID: genomics

GIST

Gastrointestinal Stromal Tumors. A form of soft tissue sarcoma, the most common mesenchymal tumors found in or near the gastrointestical tract.

CERF Crossreference annotation ID: gastrointestinal-stromal-tumors

Gleason Score

This is a prostate cancer prognosis tool that indicates the likelihood of a tumor spreading on a scale of 2 to 10. 2 is less likely to spread, and 10 is very likely to spread. More details can be found at https://en.wikipedia.org/wiki/Gleason_grading_system

CERF Crossreference annotation ID: gleason-score

Hand Foot Syndrome

Also known as Palmar-Plantar Erythrodysesthesia. Hand Foot Syndrome is characterized by redness, swelling, and pain on the palms and/or soles of the hands and feet. It can be a side effect resulting from several types of cancer treatments.

CERF Crossreference annotation ID: hand-foot-syndrome

Hapten

A small molecule that can only evoke an immune response when it is attached to a protein or other large carrier.

CERF Crossreference annotation ID: hapten

Hb

Hemoglobin (US spelling); Haemoglobin (alternate spelling). The protein in red blood cells responsible for transporting oxygen. Abnormally elevated or reduced hemoglobin counts, are associated with a number of pathologies. Several inherited single gene disorders are known to affect the structure and thus function of hemoglobin molecules.

CERF Crossreference annotation ID: hemoglobin

HCC

Hepatocellular carcinoma. This is the most prevalent form of liver cancer. HCC is a primary cancer (originating in the liver) commonly caused by Cirrhosis.

CERF Crossreference annotation ID: hepatocellular

HCL

Hairy Cell Leukemia. HCL is a B-cell leukemia in which thin, hair-like tendrils develop around the B-lymphocytes.

CERF Crossreference annotation ID: hairy-cell-leukemia

HD

Hodgkin’s Disease. HD is a type of lymphoma. Due to the expansive lymphatic system, Hodgkin’s Disease may originate nearly anywhere in the body, but most commonly originates in the lymph nodes of the upper body, particularly the neck.

CERF Crossreference annotation ID: hodgkins-disease

HER2

Human Epidermal Growth Factor Receptor 2. This is a protein that promotes the growth of cancer cells. It is caused by a gene mutation, which can occur in many types of cancer. This gene mutation only occurs in cancer cells and can not be inherited.

CERF Crossreference annotation ID: human-epidermal-growth-factor-receptor-2

H&E Staining

Hematoxylin and Eosin stain. H&E Staining utilizes hematoxylin (a basic, dark blue/violet stain) and eosin (an acidic, red/pink stain), and is the most commonly used stain for diagnosing medical issues.

CERF Crossreference annotation ID: hematoxylin-eosin-stain

HIPAA

Health Insurance Portability and Accountability Act. Established in the early 1990’s, HIPAA is a federal regulation that standardizes electronic data exchanged within health care transactions, specifies security requirements for stored or exchanged health information.

CERF Crossreference annotation ID: health-insurance-portability-accountability-act

HIV

Human Immunodeficiency Virus. HIV is a virus, contracted through contact with infected blood, semen, or vaginal secretions, that destroys CD4 cells, resulting in a compromised immune system. This is a lifelong virus that progresses into AIDS. While there is currently no cure, medication is available to slow the progression.

CERF Crossreference annotation ID: human-immunodeficiency-virus

HNPCC

Hereditary Nonpolyposis Colon Cancer. Also known as Lynch Syndrome. This is an inherited syndrome that increases the risk of developing several types of cancer, especially colorectal cancers.

CERF Crossreference annotation ID: hereditary-nonpolyposis-colon-cancer

HNSCC

Head and Neck Squamous Cell Carcinoma. Cancer occuring in the upper aerodigestive tract, in the mucous membranes of the throat, mouth, and nose. Once it metastasizes, the prognosis worsens.

CERF Crossreference annotation ID: head-neck-squamous-cell-carcinoma

Hormonal Treatment

Hormone Therapy. These medications are used to reduce and regulate the hormones in the body. Hormone therapy is a common treatment for hormone-receptor-positive breast cancer.Hormonal therapies include aromatase inhibitors, selective estrogen receptor modulators, or estrogen receptor down regulators.

CERF Crossreference annotation ID: hormonal-treatment

Hormone Receptor

A protein on the surface of or within cells which bind to specific hormones. On tumorous cells, the hormones that attach to these receptors often signal cell growth.

CERF Crossreference annotation ID: hormone-receptor

HPV

Human Papillomavirus. A very common sexually transmitted infection that often causes warts, but may lead to some types of cancer, particularly cervical cancer. There are over 150 types of HPV, each identified with a specific number.

CERF Crossreference annotation ID: human-papillomavirus

HTLV

Human T-cell Leukemia-Lymphoma Virus. This is a retrovirus that targets T-cells and may lead to T-cell cancers or a demyelinating disease. HTLV is very similar to HIV.

CERF Crossreference annotation ID: human-t-cell-leukemia-lymphoma-virus

IEC

International Electrotechnical Commission. Defines common standards that are often used as guidelines by organizations working in the histology, pathology and biorepository industries.

CERF Crossreference annotation ID: international-electrtechnical-commission

IHC

Immunohistochemistry. This method uses antigen-antibody interactions to localize particular antigens in FFPE tissues.

CERF Crossreference annotation ID: immunohistochemistry

Invasive Cancer

Cancer that has spread away from its tissue of origin.

CERF Crossreference annotation ID: invasive-cancer

IQCP

Individualized Quality Control Plan. This is a quality control policy enforced by CLIA.

CERF Crossreference annotation ID: individualized-quality-control-plan

IRB

Institutional Review Board. This is a committee that approves and oversees research involving human participants to assure compliance with all relevant ethics and regulations.

CERF Crossreference annotation ID: institutional-review-board

ISH

In Situ Hybridization. This is a common staining/screening technique in which probes are used to show the physical location of target molecules on within sectioned tissue.

CERF Crossreference annotation ID: in-situ-hybridization

ISO

International Organization for Standardization. Defines common quality standards to be utilized as guidelines in industrial commerce and research.

CERF Crossreference annotation ID: international-organization-standardization

KRAS

Kirsten rat sarcoma viral oncogene homolog. This is one of three known human RAS genes, which together are the most common oncogenes in human cancer. KRAS mutations are found in approximately 90% of pancreatic carcinomas, and in very high rates with leukemias, lung cancers, and colorectal cancers as well. KRAS is a membrane bound GTPase involved in signaling. More information can be found at https://en.wikipedia.org/wiki/KRAS

CERF Crossreference annotation ID: kirsten-rat-sarcoma-viral-oncogene-homolog

LC Codes

Laboratory Certification Codes. Established by CLIA to provide specialty and subspecialty information about the credentials of a lab. The laboratory certification codes are available on the Centers for Medicare & Medicaid Services website.

CERF Crossreference annotation ID: laboratory-certification-codes

LCH

Langerhan’s Cell Histiocytosis. This is a rare disease characterized by excess proliferation of Langerhan’s cells forming granulomas, frequently in the dermis or bones. Commonly diagnosed between ages 1 and 3.

CERF Crossreference annotation ID: langerhans-cell-histiocytosis

LIMS

Laboratory Information Management System. Used to collect data usually related to the processing of large numbers of samples or structured data from instruments.

CERF Crossreference annotation ID: laboratory-information-management-system

LMM

Lentigo Maligna Melanoma. This is a type of melanoman commonly found in skin that has suffered chronic sun damage.

CERF Crossreference annotation ID: lentigo-maligna-melanoma

Local Recurrence

When a cancer reappears in or near its place of origin.

CERF Crossreference annotation ID: local-recurrence

Lumpectomy

Surgically removing a lump from the breast.

CERF Crossreference annotation ID: lumpectomy

Malignant

In terms of tumors, malignant tumors are aggressive and are able to invade nearby tissue and metastasize to other regions of the body.

CERF Crossreference annotation ID: malignant

Mastectomy

A surgical operation that removes all or a section of the breast tissue.

CERF Crossreference annotation ID: mastectomy

MDS

Myelodysplastic Syndromes. MDS refers to a group of disorders in which disordered haematopoiesis results in insufficient quantities of viable blood cells.

CERF Crossreference annotation ID: myelodysplastic-syndromes

MEN

Multiple Endocrine Neoplasia. A group of rare inherited disorders that affect the endocrine system’s glands.

CERF Crossreference annotation ID: multiple-endocrine-neoplasia

Metastasis

The spread of cancer to other organs of the body, or the spread of the tumor from its primary site. Typically in cancers, the cancer will move to a lymph node first, then to more distant areas of the body.

CERF Crossreference annotation ID: metastasis

Mets

Metastatic cells at a secondary location.

CERF Crossreference annotation ID: metastases

MI

Myocardial Infarction, commonly referred to as a heart attack.

CERF Crossreference annotation ID: myocardial-infarction

MM

Malignant Melanoma. This is the most serious type of skin cancer.

CERF Crossreference annotation ID: malignant-melanoma

MPNST

Malignant Peripheral Nerve Sheath Tumor. A sarcoma that affects the connective tissues surrounding nerves.

CERF Crossreference annotation ID: malignant-peripheral-nerve-sheath-tumor

Molecular Diagnostics

The analysis of biomarkers in the genome and proteome.

CERF Crossreference annotation ID: molecular-diagnostics

MRT

Malignant Rhabdoid Tumor. A highly aggressive kidney tumor usually found in children.

CERF Crossreference annotation ID: malignant-rhabdoid-tumor

NAT

Normal Adjacent Tissue. This is healthy tissue with no indications of a disorder found alongside damaged or diseased tissue, typically from resected material and cadaveric specimens. Because normal, healthy tissue is not typically removed from healthy patients, researchers needing normal controls for their studies may consider whether NAT will meet the study criteria.

CERF Crossreference annotation ID: normal-adjacent-tissue

NBCCS

Nevoid Basal Cell Carcinoma Syndrome. Multiple basal cell skin cancers and jaw cysts characterize this hereditary condition. It is also known as Gorlin syndrome.

CERF Crossreference annotation ID: nevoid-basal-cell-carcinoma-syndrome

NED

No Evidence of Disease.

CERF Crossreference annotation ID: no-evidence-disease

NHL

Non-Hodgkin’s Lymphoma. This is a common cancer that originates in the lymphatic system, particularly the lymphocytes, a white blood cell.

CERF Crossreference annotation ID: non-hodgkins-lymphoma

NM

Nodular Melanoma. This is the most aggressive melanoma, characterized by its growth in depth rather than diameter. It often appears where no previous lesion existed.

CERF Crossreference annotation ID: nodular-melanoma

NMSC

Non Melanoma Skin Cancer. This includes all skin cancers that are not melanomas. The most common types are basal cell carcinoma and squamous cell carcinoma.

CERF Crossreference annotation ID: non-melanoma-skin-cancer

NPC

Nasopharyngeal Cancer. Cancer that affects the cells in the upper region of the pharynx.

CERF Crossreference annotation ID: nasopharyngeal-cancer

Node-Negative Breast Cancer

Breast cancer that has not yet spread to the lymph nodes.

CERF Crossreference annotation ID: node-negative-breast-cancer

Node-Positive Breast Cancer

Breast cancer that has invaded the lymph nodes (usually the axillary nodes).

CERF Crossreference annotation ID: node-positive-breast-cancer

NSCLC

Non-Small Cell Lung Cancer. This is the most common category of lung cancer.

CERF Crossreference annotation ID: non-small-cell-lung-cancer

OCT

Optimum Cutting Temperature. A medium used to mount tissue for sectioning in a cryostat.

CERF Crossreference annotation ID: optimum-cutting-temperature

Oncology

The analysis and treatment of cancer and tumors.

CERF Crossreference annotation ID: oncology

OS

Osteogenic Sarcoma. This is a bone cancer usually formed in the new bone tissue created during growth.

CERF Crossreference annotation ID: osteogenic-sarcoma

Pathology

1. Study of the essential nature of diseases and especially of the structural and functional changes produced by them.
2. Anatomic and physiological deviations from the normal that constitute disease or characterize a particular disease.
3. Treatise on or compilation of abnormalities.

CERF Crossreference annotation ID: pathology

Pathologic (or Histologic) Grade

The scoring of tumor cells to show how far they have evolved from a normal cell pattern. The lower the number, the closer the cells are to normal. Normal cells tend to grow and multiply slowly to form well-organized tissues made up of differentiated cells. Cancer cells are more “generic” (i.e., less differentiated into the specific cell type usually found in that tissue).

G1: Well differentiated – low grade, tends to grow slowly
G2: Moderately differentiated – Intermediate grade
G3: Poorly differentiated – High grade
G4: Undifferentiated – High grade, tends to be highly invasive.

CERF Crossreference annotation ID: pathologic-grade

Pathologic Stage

This system follows the same 1-4 scoring scheme of pathologic grade, but instead uses the TNM score to indicate the stage of the cancer. The cancer stage is not concerned with cells at the cytological level, unlike pathologic grade, but focuses more on the prognosis for the patient and characteristics of the tumor(s). The pathologic stage system is used for most cancers except hematological and brain malignancies.

CERF Crossreference annotation ID: pathologic-grade

PBMC

Peripheral Blood Mononuclear Cells. This is a broad category that includes any peripheral blood cell that features a round nucleus.

CERF Crossreference annotation ID: peripheral-blood-mononuclear-cells

PD

Parkinson’s Disease. This is a central nervous system disease that progressively affects movement.

CERF Crossreference annotation ID: parkinsons-disease

PEG

Polyethylene glycol. This electrolyte-based solution is generally used to prepare the bowel before a gastrointestinal exam.

CERF Crossreference annotation ID: polyethylene-glycol

PLB

Primary Lymphoma of Bone. This is a rare form of bone cancer.

CERF Crossreference annotation ID: primary-lymphoma-bone

PMI

Post-Mortem Interval. The time elapsed since a person’s death.

CERF Crossreference annotation ID: post-mortem-interval

PNS

Peripheral Nervous System. The system of nerves outside of the brain and spinal cord.

CERF Crossreference annotation ID: peripheral-nervous-system

Polyp

A fleshy, usually benign, tumor that grows from an organ’s mucous lining.

CERF Crossreference annotation ID: polyp

PR

Progesterone Receptor. A protein, found on cells, that progesterone molecules can attach to.

CERF Crossreference annotation ID: progesterone-receptor

PSA

Prostate-Specific Antigen. A glycoprotein enzyme in the KLK3 gene. Elevated levels of this protein, produced exclusively by the prostate, may be observed in the blood of men who have prostate diseases, including cancer.

CERF Crossreference annotation ID: prostate-specific-antigen

QA

Quality Assurance. Ensuring specimens and products meet established QC and SOP criteria.

CERF Crossreference annotation ID: quality-assurance

QC

Quality Control. Established criteria and processes to ensure good quality.

CERF Crossreference annotation ID: quality-control

Radiation Therapy

A form of cancer therapy that uses radiation to destroy cells at the site of the tumor.

CERF Crossreference annotation ID: radiation-therapy

RCC

Renal Cell Carcinoma. Cancer of the kidneys.

CERF Crossreference annotation ID: renal-cell-carcinoma

Recurrence

The reappearance of cancer post treatment.

CERF Crossreference annotation ID: recurrence

Remnant Tissue

Tissue remaining after a surgical procedure.

CERF Crossreference annotation ID: remnant-tissue

Resection

A surgical operation that removes cancerous tissue as well as normal adjacent tissue.

CERF Crossreference annotation ID: resection

RIN

RNA Integrity Number. A metric that estimates the extent of degradation of total RNA.

CERF Crossreference annotation ID: rna-integrity-number

RMS

Rhabdomyosarcoma. This is a rare cancer that affects skeletal muscle cells.

CERF Crossreference annotation ID: rhabdomyosarcoma

Sarcoma

A malignant tumor that arises from nonepithelial and connective tissue.

CERF Crossreference annotation ID: sarcoma

SCC

Squamous Cell Carcinoma. Cancer that affects squamous cells in the body. SCC has many subtypes.

CERF Crossreference annotation ID: squamous-cell-carcinoma

SCLC

Small Cell Lung Cancer. This aggressive cancer is also known as oat cell cancer.

CERF Crossreference annotation ID: small-cell-lung-cancer

Secondary Score

Any type of scoring system used for a particular type of cancer.

CERF Crossreference annotation ID: secondary-score

Sectional Planes

Reference planes to describe location. Sagittal (longitudinal, side), transverse (dorsal-ventral cross section), and coronal (longitudinal, frontal).

CERF Crossreference annotation ID: sectional-planes

SOP

Standard Operating Procedure. A formal, established process that guides operations and should be strictly followed to ensure compliance with company standards.

CERF Crossreference annotation ID: standard-operating-procedure

Synchronous Cancer

Two or more primary cancers present at the same time.

CERF Crossreference annotation ID: synchronous-cancer

Syndrome

A group of symptoms and signs which identify a particular condition.

CERF Crossreference annotation ID: syndrome

Tamoxifen

An estrogen-receptor-positive breast cancer medication that acts as an estrogen inhibitor.

CERF Crossreference annotation ID: tamoxifen

TCC

Transitional Cell Carcinoma. A cancer affecting the urinary system, usually in the bladder.

CERF Crossreference annotation ID: transitional-cell-carcinoma

TCP

Thrombocytopenia. TCP is a condition in which one has a deficiency of blood platelets.

CERF Crossreference annotation ID: thrombocytopenia

TKI

Tyrosine Kinase Inhibitor. A class of anti-cacnert drugs. More information about TKI can be found at https://www.mesothelioma-aid.org/kinhibitors.htm.

CERF Crossreference annotation ID: tyrosine-kinase-inhibitor

TNM

TNM Classification of Malignant Tumors. This is a system that uses descriptions of Tumors, Nodes, and Metastasis (TNM) to classify the extent of a cancer.

CERF Crossreference annotation ID: tumors-nodes-metastasis-classification

Tumor

A benign or malignant mass of abnormal tissue.

CERF Crossreference annotation ID: tumor

Tumor Grade

A description of a tumor based on a comparison of the abnormal cells to normal cells of the same type.

CERF Crossreference annotation ID: tumor-grade

UC

Ulcerative colitis. An inflammatory bowel disease that causes the formation of ulcers in the top layers of the large intestines’ inner lining.

CERF Crossreference annotation ID: ulcerative-colitis

UBC

Urinary Bladder Cancer.

CERF Crossreference annotation ID: urinary-bladder-cancer

WBC

White Blood Cell count. The number of white blood cells found in the body.

CERF Crossreference annotation ID: white-blood-cell-count

Wire Localization Biopsy

A breast cancer diagnoses method that is conducted when a mammogram displays abnormalities which cannot be felt.

CERF Crossreference annotation ID: wire-localization-biopsy

WM

Waldenstrom’s Macroglobulinemia. This is a rare non-Hodgkin’s lymphoma in which the excess B-lymphocytes produce an antibody, immunoglobulins.

CERF Crossreference annotation ID: waldenstroms-macroglobulinemia

YST

Yolk Sac Tumor. Also known as a germ cell tumor, this rare cancer affects the cells lining the embryo’s yolk sac, and is then usually seen in the ovaries, testes, or sacrococcygeal area.

CERF Crossreference annotation ID: yolk-sac-tumor